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A 438079 (Standard)

A 438079 (Standard) is the analytical standard of A 438079. This product is intended for research and analytical applications. A 438079 is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.

Product Specifications

CAS Number

899507-36-9

UNSPSC

12352100

Target

P2X Receptor; Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Neurological Disease

Smiles

ClC1=C(Cl)C(C2=NN=NN2CC3=CC=CN=C3)=CC=C1

Molecular Formula

C13H9Cl2N5

Molecular Weight

306.15

References & Citations

[1]McGaraughty S, et al. P2X7-related modulation of pathological nociception in rats. Neuroscience. 2007 Jun 8;146 (4) :1817-28.|[2]Mesuret G, et al. CNS Neurosci Ther. 2014 Jun;20 (6) :556-64.|[3]Marcellino D, et al. On the role of P2X (7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X (7) receptor antagonist A-438079. J Neural Transm (Vienna) . 2010 Jun;117 (6) :681-7.|[4]Martins JP, et al. The role of P2X7 purinergic receptors in inflammatory and nociceptive changes accompanying cyclophosphamide-induced haemorrhagic cystitis in mice. Br J Pharmacol. 2012 Jan;165 (1) :183-96.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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