Salubrinal (Standard)

Salubrinal (Standard) is the analytical standard of Salubrinal. This product is intended for research and analytical applications. Salubrinal is a cell-permeable and selective inhibitor of eIF2α dephosphorylation[1]. Salubrinal acts as a dual-specificity phosphatase 2 (Dusp2) inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis[2]. Salubrinal has antiviral activity against HSV-1 and inhibits dephosphorylation of eIF2α mediated by the HSV-1 protein ICP34.5[3].

Product Specifications

CAS Number

[405060-95-9]

UNSPSC

12352100

Target

Apoptosis; Autophagy; HSV; Phosphatase; Reference Standards

Related Pathways

Anti-infection; Apoptosis; Autophagy; Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Infection; Inflammation/Immunology

Smiles

O=C(NC(NC(NC1=CC=CC2=C1N=CC=C2)=S)C(Cl)(Cl)Cl)/C=C/C3=CC=CC=C3

Molecular Formula

C21H17Cl3N4OS

Molecular Weight

479.80

References & Citations

[1]Drexler HC. Synergistic Apoptosis Induction in Leukemic Cells by the Phosphatase Inhibitor Salubrinal and Proteasome Inhibitors. PLoS One. 2009;4 (1) :e4161.|[2]Hamamura K, et al. Salubrinal acts as a Dusp2 inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis. Cell Signal. 2015 Apr;27 (4) :828-35.|[3]Bryant KF, et al. ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells. Virology. 2008 Sep 30;379 (2) :197-204.