Pifithrin-α (hydrobromide) (Standard)
Pifithrin-α (hydrobromide) (Standard) is the analytical standard of Pifithrin-α (hydrobromide) . This product is intended for research and analytical applications. Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.
Product Specifications
CAS Number
63208-82-2
UNSPSC
12352100
Target
Apoptosis; Aryl Hydrocarbon Receptor; Ferroptosis; MDM-2/p53; Reference Standards
Related Pathways
Apoptosis; Immunology/Inflammation; Others
Field of Research
Cancer
Smiles
N=C1SC2=C(CCCC2)N1CC(C3=CC=C(C)C=C3)=O.[H]Br
Molecular Formula
C16H19BrN2OS
Molecular Weight
367.30
References & Citations
[1]Yu W, et al. Cyclosporine A Suppressed Glucose Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition. Int J Biol Sci. 2016 Jan 1;12 (2) :198-209.|[2]Hoagland MS, et al. The p53 Inhibitor Pifithrin-α Is a Potent Agonist of the Aryl Hydrocarbon Receptor. J Pharmacol Exp Ther. 2005 Aug;314 (2) :603-10.|[3]Kuang SQ, et al. FOXE3 mutations predispose to thoracic aortic aneurysms and dissections. J Clin Invest. 2016 Mar 1;126 (3) :948-61.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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