Pifithrin-α (hydrobromide) (Standard)

Pifithrin-α (hydrobromide) (Standard) is the analytical standard of Pifithrin-α (hydrobromide) . This product is intended for research and analytical applications. Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.

Product Specifications

CAS Number

[63208-82-2]

UNSPSC

12352100

Target

Apoptosis; Aryl Hydrocarbon Receptor; Ferroptosis; MDM-2/p53; Reference Standards

Related Pathways

Apoptosis; Immunology/Inflammation; Others

Field of Research

Cancer

Smiles

N=C1SC2=C(CCCC2)N1CC(C3=CC=C(C)C=C3)=O.[H]Br

Molecular Formula

C16H19BrN2OS

Molecular Weight

367.30

References & Citations

[1]Yu W, et al. Cyclosporine A Suppressed Glucose Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition. Int J Biol Sci. 2016 Jan 1;12 (2) :198-209.|[2]Hoagland MS, et al. The p53 Inhibitor Pifithrin-α Is a Potent Agonist of the Aryl Hydrocarbon Receptor. J Pharmacol Exp Ther. 2005 Aug;314 (2) :603-10.|[3]Kuang SQ, et al. FOXE3 mutations predispose to thoracic aortic aneurysms and dissections. J Clin Invest. 2016 Mar 1;126 (3) :948-61.