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20-Hydroxyvitamin D3

20-Hydroxyvitamin D3 (20 (OH) D3) is a hydroxy metabolite of vitamin D3. 20-Hydroxyvitamin D3 functions as a ligand for vitamin D receptor (VDR), aryl hydrocarbon receptor (AhR), liver X receptor (LXR), and retinoic acid-related orphan receptor (ROR) . 20-Hydroxyvitamin D3 inhibits cell proliferation, induces differentiation. 20-Hydroxyvitamin D3 can be used for inflammatory and autoimmune diseases study[1].

Product Specifications

CAS Number

[651734-12-2]

Product Name Alternative

20 (OH) D3; 20S-Hydroxyvitamin D3

UNSPSC

12352211

Target

Aryl Hydrocarbon Receptor; LXR; ROR; VD/VDR

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Purity

98.0

Smiles

C=C1CC[C@H](O)C/C1=C/C=C2[C@@](CC[C@]3([H])[C@@](C)(O)CCCC(C)C)([H])[C@]3(C)CCC/2

Molecular Formula

C27H44O2

Molecular Weight

400.64

References & Citations

[1]Brzeminski P, et al. Chemical synthesis, biological activities and action on nuclear receptors of 20S (OH) D3, 20S,25 (OH) 2D3, 20S,23S (OH) 2D3 and 20S,23R (OH) 2D3. Bioorg Chem. 2022 Apr;121:105660.

Shipping Conditions

Dry Ice

Storage Conditions

-80°C, sealed storage, away from moisture and light

Scientific Category

Natural Products

Clinical Information

No Development Reported

Curated Selection

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