ZM323881 (hydrochloride) (Standard)
ZM323881 (hydrochloride) (Standard) is the analytical standard of ZM323881 (hydrochloride) . This product is intended for research and analytical applications. ZM323881 hydrochloride is a potent and selective VEGFR2 inhibitor with an IC50 of less than 2 nM.
Product Specifications
CAS Number
193000-39-4
UNSPSC
12352100
Target
Reference Standards; VEGFR
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CC1=C(O)C=C(NC2=C3C=CC(OCC4=CC=CC=C4)=CC3=NC=N2)C(F)=C1.Cl
Molecular Formula
C22H19ClFN3O2
Molecular Weight
411.86
References & Citations
[1]Whittles CE, et al. ZM323881, a novel inhibitor of vascular endothelial growth factor-receptor-2 tyrosine kinase activity. Microcirculation. 2002 Dec;9 (6) :513-22.|[2]Endo A, et al. Selective inhibition of vascular endothelial growth factor receptor-2 (VEGFR-2) identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF. J Recept Signal Transduct Res. 2003;23 (2-3) :239-54.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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