ZM323881 (hydrochloride) (Standard)

ZM323881 (hydrochloride) (Standard) is the analytical standard of ZM323881 (hydrochloride) . This product is intended for research and analytical applications. ZM323881 hydrochloride is a potent and selective VEGFR2 inhibitor with an IC50 of less than 2 nM.

Product Specifications

CAS Number

[193000-39-4]

UNSPSC

12352100

Target

Reference Standards; VEGFR

Related Pathways

Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

CC1=C(O)C=C(NC2=C3C=CC(OCC4=CC=CC=C4)=CC3=NC=N2)C(F)=C1.Cl

Molecular Formula

C22H19ClFN3O2

Molecular Weight

411.86

References & Citations

[1]Whittles CE, et al. ZM323881, a novel inhibitor of vascular endothelial growth factor-receptor-2 tyrosine kinase activity. Microcirculation. 2002 Dec;9 (6) :513-22.|[2]Endo A, et al. Selective inhibition of vascular endothelial growth factor receptor-2 (VEGFR-2) identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF. J Recept Signal Transduct Res. 2003;23 (2-3) :239-54.