Selisistat (Standard)
Selisistat (Standard) is the analytical standard of Selisistat. This product is intended for research and analytical applications. Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC50 of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease[1][2].
Product Specifications
CAS Number
49843-98-3
UNSPSC
12352100
Hazard Statement
H302, H315, H319, H335
Target
Reference Standards; Sirtuin
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Others
Field of Research
Cancer; Inflammation/Immunology
Purity
99.93
Smiles
O=C(C1C(NC2=C3C=C(Cl)C=C2)=C3CCC1)N
Molecular Formula
C13H13ClN2O
Molecular Weight
248.71
Precautions
H302, H315, H319, H335
References & Citations
[1]Smith MR, et al. A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease. Hum Mol Genet. 2014;23 (11) :2995-3007.|[2]Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1 [published correction appears in J Med Chem. 2007 Mar 8;50 (5) :1086]. J Med Chem. 2005;48 (25) :8045-8054.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Available Sizes
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