Tezacaftor-d6
Tezacaftor-d6 (VX-661-d6) is deuterium labeled Tezacaftor. Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation[1][2][3][4].
Product Specifications
CAS Number
1961280-94-3
Product Name Alternative
VX-661-d6
UNSPSC
12352005
Target
CFTR; Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
FC1=C(NC(C2(CC2)C3=CC=C4OC(OC4=C3)(F)F)=O)C=C5C(N(C[C@H](CO)O)C(C(C([2H])([2H])[2H])(CO)C([2H])([2H])[2H])=C5)=C1
Molecular Formula
C26H21D6F3N2O6
Molecular Weight
526.53
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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