Fostemsavir-d8

Fostemsavir-d8 (BMS-663068-d8) is deuterium labeled Fostemsavir. Fostemsavir (BMS-663068) is the phosphonooxymethyl prodrug of BMS-626529. Fostemsavir (BMS-663068) is a novel attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells.

Product Specifications

Product Name Alternative

BMS-663068-d8

UNSPSC

12352005

Target

HIV; Isotope-Labeled Compounds

Related Pathways

Anti-infection; Others

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

O=C(C1=CN(COP(O)(O)=O)C2=C1C(OC)=CN=C2N3N=C(C)N=C3)C(N4C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C4([2H])[2H])C(C5=CC=CC=C5)=O)=O

Molecular Formula

C25H18D8N7O8P

Molecular Weight

591.54

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Nowicka-Sans B, et al. In vitro antiviral characteristics of HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068. Antimicrob Agents Chemother. 2012 Jul;56 (7) :3498-507.