Quisinostat (hydrochloride)

Quisinostat (JNJ-26481585) hydrochloride is a potent and orally active pan-HDAC inhibitor (HDACi), with IC50 values ranging from 0.11 nM to 0.64 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11. Quisinostat hydrochloride has a broad spectrum antitumoral activity. Quisinostat hydrochloride can induce autophagy in neuroblastoma cells[1][2].

Product Specifications

CAS Number

[1083078-98-1]

Product Name Alternative

JNJ26481585 (hydrochloride)

UNSPSC

12352005

Target

Autophagy; HDAC

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Smiles

O=C(NO)C1=CN=C(N=C1)N2CCC(CC2)CNCC3=CN(C4=C3C=CC=C4)C.Cl

Molecular Formula

C21H27ClN6O2

Molecular Weight

430.93

References & Citations

[1]Vamsi Krishna Kommalapati, et al. Inhibition of JNJ-26481585-mediated autophagy induces apoptosis via ROS activation and mitochondrial membrane potential disruption in neuroblastoma cells. Mol Cell Biochem. 2020 May;468 (1-2) :21-34.|[2]Arts J, et al. JNJ-26481585, a novel "second-generation" oral histone deacetylase inhibitor, shows broad-spectrum preclinical antitumoral activity. Clin Cancer Res. 2009 Nov 15;15 (22) :6841-51.