Capivasertib (Standard)

Capivasertib (Standard) is the analytical standard of Capivasertib. This product is intended for research and analytical applications. Capivasertib (AZD5363) is an orally active and potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1, Akt2 and Akt3, respectively.

Product Specifications

CAS Number

[1143532-39-1]

UNSPSC

12352100

Target

Akt; Autophagy; Reference Standards

Related Pathways

Autophagy; Others; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

O=C(C1(N)CCN(C2=C3C(NC=C3)=NC=N2)CC1)N[C@H](C4=CC=C(Cl)C=C4)CCO

Molecular Formula

C21H25ClN6O2

Molecular Weight

428.92

References & Citations

[1]Davies BR, et al. Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background. Mol Cancer Ther. 2012 Apr;11 (4) :873-87.