Sacubitril (Standard)
Sacubitril (Standard) is the analytical standard of Sacubitril. This product is intended for research and analytical applications. Sacubitril (AHU-377) is a potent and orally active NEP (neprilysin) inhibitor with an IC50 of 5 nM. Sacubitril is a component of the heart failure medicine LCZ696. Sacubitril can be used for the research of heart failure, hypertension and COVID-19[1][2][3].
Product Specifications
CAS Number
149709-62-6
UNSPSC
12352100
Target
Neprilysin; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Infection; Cardiovascular Disease
Smiles
O=C(CCC(O)=O)N[C@H](CC1=CC=C(C2=CC=CC=C2)C=C1)C[C@@H](C)C(OCC)=O
Molecular Formula
C24H29NO5
Molecular Weight
411.49
References & Citations
[1]Ksander GM, et al. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J Med Chem. 1995 May 12;38 (10) :1689-700.|[2]Voors AA, et al. The potential role of valsartan + AHU377 (LCZ696) in the treatment of heart failure. Expert Opin Investig Drugs. 2013 Aug;22 (8) :1041-7.|[3]von Lueder TG, et al. Angiotensin receptor neprilysin inhibitor LCZ696 attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy. Circ Heart Fail. 2015 Jan;8 (1) :71-8.|[4]Hegde, L.G., et al. Comparative efficacy of AHU-377, a potent neprilysin inhibitor, in two rat models of volume-dependent hypertension. BMC Pharmacol 11, P33 (2011) .
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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