BBT-176
BBT-176 is an orally effective EGFR inhibitor. BBT-176 has inhibitory activity against multiple EGFR C797S mutant cell lines. BBT-176 is commonly used in cancer research[1].
Product Specifications
CAS Number
2254805-44-0
UNSPSC
12352100
Target
EGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=S(NC1=C(NC2=NC(NC3=CC=C(N4CCC(CC4)N5CCN(CC5)C)C=C3OC)=NC=C2Cl)C=CC=C1)(C)=O
Molecular Formula
C28H37ClN8O3S
Molecular Weight
601.16
References & Citations
[1]Lim SM, et al. BBT-176, a Novel Fourth-Generation Tyrosine Kinase Inhibitor for Osimertinib-Resistant EGFR Mutations in Non-Small Cell Lung Cancer. Clin Cancer Res. 2023 Aug 15;29 (16) :3004-3016.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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