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(Rac) -Rotigotine (hydrochloride) (Standard)

(Rac) -Rotigotine (hydrochloride) (Standard) is the analytical standard of (Rac) -Rotigotine (hydrochloride) . This product is intended for research and analytical applications. (Rac) -Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Kis of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

Product Specifications

UNSPSC

12352100

Target

5-HT Receptor; Adrenergic Receptor; Dopamine Receptor; Reference Standards

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Endocrinology; Neurological Disease

Smiles

OC1=C2CCC(N(CCC)CCC3=CC=CS3)CC2=CC=C1.[H]Cl

Molecular Formula

C19H26ClNOS

Molecular Weight

351.93

References & Citations

[1]Wood M, et al. Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors. Br J Pharmacol. 2015 Feb;172 (4) :1124-35.|[2]Scheller D, et al. The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379 (1) :73-86.|[3] Fenu S, et al. In vivo dopamine agonist properties of rotigotine: Role of D1 and D2 receptors. Eur J Pharmacol. 2016 Oct 5;788:183-91.|[4]Radad K, et al. Neuroprotective effect of rotigotine against complex I inhibitors, MPP+ and rotenone, in primary mesencephalic cell culture. Folia Neuropathol. 2014;52 (2) :179-86.

Shipping Conditions

Room temperature

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-15394R/

Scientific Category

Reference Standards

CAS Number

[102120-99-0]

Available Sizes

Curated Selection

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