Pimicotinib (hydrochloride)
Pimicotinib (ABSK021) hydrochloride is a selective and orally active CSF1R inhibitor with an IC50 value of 19.48 nM (determined by inhibiting ADP production) . Pimicotinib hydrochloride exhibits anti-tumor activity[1][2][3].
Product Specifications
Product Name Alternative
ABSK021 (hydrochloride)
UNSPSC
12352005
Target
C-Fms; c-Kit; PDGFR
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(N1C(C(C)(CC1)C)=O)NC2=CC=C(OC3=CC=NC(C4=CN(C)N=C4)=C3)C(C)=N2.Cl
Molecular Formula
C22H25ClN6O3
Molecular Weight
456.93
References & Citations
[1]Zhao BW, et al. N- (azaaryl) cyclolactam-1-carboxamide derivative, preparation method and application. World Intellectual Property Organization, WO2018214867 A1. 2018-11-29.|[2]Zhang N, et al. Abstract LB077: CSF-1R inhibition with Pimicotinib (ABSK021) enhanced anti-tumor efficacy of KRASG12C inhibitors in preclinical non-small cell lung cancer mouse models. Cancer Research, 2024, 84 (7_Supplement) : LB077-LB077.|[3]Yang S, et al. Abstract LB-288: A highly selective small molecule CSF-1R inhibitor demonstrates strong immunomodulatory activity in syngeneic models. Cancer Research, 2018, 78 (13_Supplement) : LB-288-LB-288.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-153920A/
Scientific Category
Reference compound1
Clinical Information
Phase 3
CAS Number
[2866305-19-1]
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