Lucitanib (Standard)
Lucitanib (Standard) is the analytical standard of Lucitanib. This product is intended for research and analytical applications. Lucitanib (E-3810) is a novel dual inhibitor of VEGFR and FGFR, potently and selectively inhibits VEGFR1, VEGFR2, VEGFR3, FGFR1 and FGFR2 with IC50s of 7 nM, 25 nM, 10 nM, 17.5 nM, and 82.5 nM, respectively[1][2][3].
Product Specifications
CAS Number
1058137-23-7
UNSPSC
12352100
Target
FGFR; Reference Standards; VEGFR
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(NC)C1=CC=CC2=C1C=CC(OC3=CC=NC4=CC(OCC5(N)CC5)=C(OC)C=C43)=C2
Molecular Formula
C26H25N3O4
Molecular Weight
443.49
References & Citations
[1]Bello E, et al. E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical models. Cancer Res. 2011 Feb 15;71 (4) :1396-405.|[2]Colzani M, et al. Quantitative chemical proteomics identifies novel targets of the anti-cancer multi-kinase inhibitor E-3810. Mol Cell Proteomics. 2014 Jun;13 (6) :1495-509.|[3]Bello E, et al. The tyrosine kinase inhibitor E-3810 combined with NSC 125973 inhibits the growth of advanced-stage triple-negative breast cancer xenografts. Mol Cancer Ther. 2013 Feb;12 (2) :131-40
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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