LacCer (d18:1/16:0)

LacCer (d18:1/16:0) (C16 Lactosylceramide (d18:1/16:0) ) is an endogenous bioactive sphingolipid that can form membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors (GPCRs) . The levels of LacCer (d18:1/16:0) are elevated in the plasma of insulin-resistant cattle. In a mouse model of Niemann-Pick type C1 disease (a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder), the expression of LacCer (d18:1/16:0) is also upregulated. LacCer (d18:1/16:0) can be used in research on metabolic diseases and neurodegenerative diseases[1][2][3].

Product Specifications

CAS Number

[4201-62-1]

Product Name Alternative

C16 Lactosylceramide (d18:1/16:0)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Neurological Disease

Purity

Smiles

OC[C@@H](O[C@H]([C@@H]([C@H]1O)O)OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(CCCCCCCCCCCCCCC)=O)[C@H]1O[C@@H]2O[C@@H]([C@@H]([C@@H]([C@H]2O)O)O)CO

Molecular Formula

C46H87NO13

Molecular Weight

862.18

Precautions

H302, H315, H319, H335

References & Citations

[1]Rico JE, et al. Plasma ceramides are elevated in overweight Holstein dairy cows experiencing greater lipolysis and insulin resistance during the transition from late pregnancy to early lactation. J Dairy Sci. 2015 Nov;98 (11) :7757-70.|[2]Praggastis M, et al. A murine Niemann-Pick C1 I1061T knock-in model recapitulates the pathological features of the most prevalent human disease allele. J Neurosci. 2015 May 27;35 (21) :8091-106.|[3]Iwabuchi K, et al. Role of Ceramide from Glycosphingolipids and Its Metabolites in Immunological and Inflammatory Responses in Humans. Mediators Inflamm. 2015;2015:120748.