Fenretinide (Standard)
Fenretinide (Standard) is the analytical standard of Fenretinide. This product is intended for research and analytical applications. Fenretinide (4-HPR) is a synthetic retinoid deriverative, binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death.
Product Specifications
CAS Number
65646-68-6
Product Name Alternative
4-HPR (Standard) ; ISLA-101 (Standard)
UNSPSC
12352005
Target
Autophagy; RAR/RXR; Reference Standards
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
CC(/C=C/C=C(/C=C/C1=C(CCCC(C)1C)C)C)=C\C(NC2=CC=C(O)C=C2)=O
Molecular Formula
C26H33NO2
Molecular Weight
391.55
References & Citations
[1]Apraiz, Aintzane., et al. Dihydroceramide accumulation and reactive oxygen species are distinct and nonessential events in 4-HPR-mediated leukemia cell death. Biochemistry and Cell Biology (2012), 90 (2), 209-223.|[2]Bikman, Benjamin T., et al. Fenretinide Prevents Lipid-induced Insulin Resistance by Blocking Ceramide Biosynthesis. Journal of Biological Chemistry (2012), 287 (21), 17426-17437.|[3]Cooper JP, et al. Fenretinide metabolism in humans and mice: utilizing pharmacological modulation of its metabolic pathway to increase systemic exposure. Br J Pharmacol. 2011 Jul;163 (6) :1263-75.|[4]Golubkov V, et al. Action of fenretinide (4-HPR) on ovarian cancer and endothelial cells. Anticancer Res. 2005 Jan-Feb;25 (1A) :249-53.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
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