MRL-436
MRL-436 is a RNA polymerase inhibitor with antibacterial activity. MRL-436 exerts its antibacterial activity dependent on residue 622 of the RNA polymerase β' subunit and the RNAP ω subunit. MRL-436 inhibits Rifampicin -resistant RNA polymerase derivatives and exhibits antibacterial activity against Rifampicin-resistant strains[1].
Product Specifications
CAS Number
2095432-38-3
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Bacterial; DNA/RNA Synthesis
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
O=C(C1=CC=CN2C1=NN=C2CC(C)C)NC3C4=C(C5=C3C=CC=C5)C=CC=C4
Molecular Formula
C24H22N4O
Molecular Weight
382.46
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501
References & Citations
[1]Walker SS, et al. Affinity Selection-Mass Spectrometry Identifies a Novel Antibacterial RNA Polymerase Inhibitor. ACS Chem Biol. 2017 May 19;12 (5) :1346-1352.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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