LD4172
LD4172 is a PROTAC degrader for RIP kinase (RIPK1) with DC50 in nanomolare levels. LD4172 induces apoptosis in cell B16F10 with combination of TNF-α. LD4172 exhibits antitumor efficacy in mouse models[1]. (Pink: ligand for target protein (HY-170613) ; Black: linker (HY-W012241) ; Blue: ligand for E3 ligase VHL (HY-112078) )
Product Specifications
CAS Number
[2782022-40-4]
UNSPSC
12352005
Target
PROTACs; RIP kinase
Related Pathways
Apoptosis; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
98.32
Solubility
DMSO : 100 mg/mL
Smiles
O=C(CC1=CC=CC(OC(F)(F)F)=C1)N2CCC3=C2C=CC(C4=CN(C5=NC=NC(N)=C45)CCCNC(CCCCCCCCCCC(N[C@H](C(N6C[C@@H](C[C@H]6C(N[C@H](C7=CC=C(C=C7)C8=C(N=CS8)C)C)=O)O)=O)C(C)(C)C)=O)=O)=C3
Molecular Formula
C61H75F3N10O7S
Molecular Weight
1149.37
References & Citations
[1]Yu X, et al., Development of a RIPK1 degrader to enhance antitumor immunity. Nat Commun. 2024 Dec 16;15 (1) :10683.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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