Sirtuin-IN-1
Sirtuin-IN-1 (Compound 18) is a SIRT1/2 inhibitor (IC50s: 6.2 μM and 4.2μM for SIRT1 and SIRT2, respectively) . Sirtuin-IN-1 induces G1 cell cycle arrest. Sirtuin-IN-1 exhibits potent anti-cancer activity against glioma[1].
Product Specifications
CAS Number
1392810-44-4
UNSPSC
12352005
Target
Sirtuin
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
N#CC1=CC=CC(=C1)NC(=O)NC2C3=CC(=CC=C3OC(C)(C)C2)NC(=O)OC(C)(C)C
Molecular Formula
C24H28N4O4
Molecular Weight
436.51
References & Citations
[1]Schnekenburger M, et al. Discovery and Characterization of R/S-N-3-Cyanophenyl-N'- (6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl) urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines. J Med Chem. 2017 Jun 8;60 (11) :4714-4733.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT1; SIRT2
Frequently Asked Questions
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