Sirtuin-IN-1

Sirtuin-IN-1 (Compound 18) is a SIRT1/2 inhibitor (IC50s: 6.2 μM and 4.2μM for SIRT1 and SIRT2, respectively) . Sirtuin-IN-1 induces G1 cell cycle arrest. Sirtuin-IN-1 exhibits potent anti-cancer activity against glioma[1].

Product Specifications

CAS Number

[1392810-44-4]

UNSPSC

12352005

Target

Sirtuin

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Smiles

N#CC1=CC=CC(=C1)NC(=O)NC2C3=CC(=CC=C3OC(C)(C)C2)NC(=O)OC(C)(C)C

Molecular Formula

C24H28N4O4

Molecular Weight

436.51

References & Citations

[1]Schnekenburger M, et al. Discovery and Characterization of R/S-N-3-Cyanophenyl-N'- (6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl) urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines. J Med Chem. 2017 Jun 8;60 (11) :4714-4733.