ErSO-TFPy

ErSO-TFPy activates the sodium channel TRPM4, causes an imbalance of intracellular calcium and sodium ions. ErSO-TFPy exhibits low nanomolar cytotoxicity in ERα+ breast cancer cell lines (IC50 = 5-25 nM) through induction of necrosis. ErSO-TFPy exhbits antitumor efficacy in mouse models[1].

Product Specifications

CAS Number

[3035547-78-2]

UNSPSC

12352005

Target

Sodium Channel; TRP Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.33

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1[C@@](N2CC(F)(C(F)(C2)F)F)(C3=CC=C(C=C3)O)C4=CC=CC(C(F)(F)F)=C4N1

Molecular Formula

C19H13F7N2O2

Molecular Weight

434.31

References & Citations

[1]Mulligan MP, et al., Single Dose of a Small Molecule Leads to Complete Regressions of Large Breast Tumors in Mice. ACS Cent Sci. 2025 Jan 22;11 (2) :228-238.