Tetrahydrouridine
Tetrahydrouridine dihydrate is potent inhibitor of cytidine deaminase (CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine[1][2].
Product Specifications
CAS Number
18771-50-1
Product Name Alternative
THU; NSC-112907
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.91
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O=C1N([C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)CCC(O)N1
Molecular Formula
C9H16N2O6
Molecular Weight
248.23
Precautions
H302, H315, H319, H335
References & Citations
[1]Funamizu N, et al. Tetrahydrouridine inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels. PLoS One. 2012;7 (5) :e37424.|[2]Terse P, et al. Subchronic oral toxicity study of decitabine in combination with tetrahydrouridine in CD-1 mice. Int J Toxicol. 2014 Mar-Apr;33 (2) :75-85.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Citation 01
Int J Nanomedicine. 2024 Dec 11:19:13391-13410.|Biochem Biophys Res Commun. 2023 Sep 10:672:193-200.
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