Tetrahydrouridine

Tetrahydrouridine dihydrate is potent inhibitor of cytidine deaminase (CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine[1][2].

Product Specifications

CAS Number

[18771-50-1]

Product Name Alternative

THU; NSC-112907

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.91

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C1N([C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)CCC(O)N1

Molecular Formula

C9H16N2O6

Molecular Weight

248.23

Precautions

H302, H315, H319, H335

References & Citations

[1]Funamizu N, et al. Tetrahydrouridine inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels. PLoS One. 2012;7 (5) :e37424.|[2]Terse P, et al. Subchronic oral toxicity study of decitabine in combination with tetrahydrouridine in CD-1 mice. Int J Toxicol. 2014 Mar-Apr;33 (2) :75-85.