Tetrahydrouridine (dihydrate)
Tetrahydrouridine dihydrate (THU dihydrate) is potent inhibitor of cytidine deaminase (CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine.
Product Specifications
Product Name Alternative
THU (dihydrate) ; NSC-112907 (dihydrate)
UNSPSC
12352005
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.86
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N([C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)CCC(O)N1.[H]O[H].[H]O[H]
Molecular Formula
C9H20N2O8
Molecular Weight
284.26
References & Citations
[1]Funamizu N, et al. Tetrahydrouridine inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels. PLoS One. 2012;7 (5) :e37424.|[2]Terse P, et al. Subchronic oral toxicity study of decitabine in combination with tetrahydrouridine in CD-1 mice. Int J Toxicol. 2014 Mar-Apr;33 (2) :75-85.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Citation 01
Biochem Biophys Res Commun. 2023 Sep 10:672:193-200.|Int J Nanomedicine. 2024 Dec 11:19:13391-13410.
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