(rel) -PRT062607
(rel) -PRT062607 ((rel) -P505-15) is the relative configuration of PRT062607. PRT062607 is a highly selective inhibitor of Syk kinase, with an IC50 value of 1-2 nM, and is more than 80 times less potent against Fgr, Lyn, FAK, Pyk2, and Zap70.
Product Specifications
CAS Number
1194954-52-3
Product Name Alternative
(rel) -P505-15; (rel) -PRT-2607; (rel) -BIIB-057
UNSPSC
12352100
Target
Drug Isomer; Syk
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
NC(C(C(NC1=CC(N2N=CC=N2)=CC=C1)=N3)=CN=C3N[C@H]4[C@H](CCCC4)N)=O
Molecular Formula
C19H23N9O
Molecular Weight
393.45
References & Citations
[1]Coffey G, et al. Specific inhibition of spleen tyrosine kinase suppresses leukocyte immune function and inflammation in animal models of rheumatoid arthritis. J Pharmacol Exp Ther. 2012 Feb;340 (2) :350-9.|[2]Spurgeon SE, et al. The selective SYK inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo and augments the activity of fludarabine in chronic lymphocytic leukemia. J Pharmacol Exp Ther. 2013 Feb;344 (2) :378-87.|[3]Hoellenriegel J, et al. Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migration. Leukemia. 2012 Jul;26 (7) :1576-83.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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