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Org 274179-0

Org 274179-0 is a potent and allosteric antagonist of thyroid-stimulating hormone (TSH) receptor, with an IC50 of nanomolar concentration. Org 274179-0 completely inhibits TSH (and TSI) -mediated TSH receptor activation with little effect on the potency of TSH. Org 274179-0 can be used for the research of Graves' disease (GD) [1].

Product Specifications

CAS Number

1421683-12-6

UNSPSC

12352005

Target

TSH Receptor

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Purity

98.60

Smiles

C[C@]1(C2=CC=CC=C2)C3=CC(NC(CCC4=CC(C(F)(F)F)=CC=C4)=O)=CC=C3N(CC1)C(C)=O

Molecular Formula

C28H27F3N2O2

Molecular Weight

480.52

References & Citations

[1]Koppen CJ, et, al. Mechanism of action of a nanomolar potent, allosteric antagonist of the thyroid-stimulating hormone receptor. Br J Pharmacol. 2012 Apr;165 (7) :2314-24.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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