MC-Phe-Lys (MMT) -PABOH

MC-Phe-Lys (MMT) -PABOH is a linker. MC-Phe-Lys (MMT) -PABOH can be used to synthesize the immunoconjugate BR96-Phe-Lys-PABC-DOX. MC-Phe-Lys (MMT) -PABOH can be used in the research of colorectal cancer and ovarian cancer[1][2].

Product Specifications

CAS Number

[159857-65-5]

UNSPSC

12352005

Target

Drug Intermediate

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(C=CC1=O)N1CCCCCC(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(NC3=CC=C(C=C3)CO)=O)CCCCNC(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=C(C=C6)OC)=O)=O

Molecular Formula

C52H57N5O7

Molecular Weight

864.04

References & Citations

[1]Dubowchik GM, et al. Cathepsin B-labile dipeptide linkers for lysosomal release of doxorubicin from internalizing immunoconjugates: model studies of enzymatic drug release and antigen-specific in vitro anticancer activity. Bioconjug Chem. 2002 Jul-Aug;13 (4) :855-69. |[2]Yao H, et al. Methods to Design and Synthesize Antibody-Drug Conjugates (ADCs) . Int J Mol Sci. 2016 Feb 2;17 (2) :194.