(-) -IHCH7041
(-) -IHCH7041 (Compound (-) - (S) -I-10) is a selective and orally active dopamine D2 receptor agonist with a Ki of 22.44 nM. (-) -IHCH7041 can activate Gαi1 protein and β-arrestin2 signaling pathway with EC50 values of 1.38 and 2.75 nM. (-) -IHCH7041 can improve cognitive impairment and memory capacity. (-) -IHCH7041 can be used for the research of neurological disease, such as Alzheimer's disease[1].
Product Specifications
CAS Number
[2813335-07-6]
UNSPSC
12352005
Target
Dopamine Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
CN(C)C(N[C@@H](CC1)CC[C@H]1CCN2C[C@@]3([H])N(CC2)C4=CC=CC5=C4C(C3)=CN5)=O
Molecular Formula
C24H35N5O
Molecular Weight
409.57
References & Citations
[1]Jianjun Cheng, et al. Aza-ergoline derivative and preparation method and application thereof. CN114835709A. 2023-10-20
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D2 Receptor
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