MRS542
MRS542 is a nucleoside A3 AR antagonist with a pKi of 8.74. MRS542 also acts as a partial agonist (pEC50 = 7.76) in promoting β-arrestin translocation. MRS542 can be converted into an agonist by LUF6000. MRS542 can be used for cardiovascular disease research[1][2].
Product Specifications
CAS Number
163152-31-6
UNSPSC
12352005
Target
Adenosine Receptor; Arrestin
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Smiles
N(CC1=CC(I)=CC=C1)C2=C3C(N(C=N3)[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)=NC(Cl)=N2
Molecular Formula
C17H17ClIN5O4
Molecular Weight
517.71
References & Citations
[1]Gao ZG, et al. Translocation of arrestin induced by human A (3) adenosine receptor ligands in an engineered cell line: comparison with G protein-dependent pathways. Pharmacol Res. 2008 Apr;57 (4) :303-11.|[2]Gao ZG, et al. Flexible modulation of agonist efficacy at the human A3 adenosine receptor by the imidazoquinoline allosteric enhancer LUF6000. BMC Pharmacol. 2008 Dec 12;8:20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Adenosine A3 receptor (A3R)
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