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(1R,2R) -Elpipodect

(1R,2R) -Elpipodect ((1R,2R) -MK-8189) is the (1R,2R) enantiomer of Elpipodect. Elpipodect (MK-8189) is an orally active and selective PDE10A inhibitor with a Ki of 29 pM. Elpipodect can be used in research of schizophrenia[1].

Product Specifications

CAS Number

1424378-99-3

Product Name Alternative

(1R,2R) -MK-8189

UNSPSC

12352100

Target

Phosphodiesterase (PDE)

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Neurological Disease

Smiles

CC(S1)=NN=C1CNC2=CC(OC[C@H]3[C@H](C4=CC=C(C=N4)C)C3)=NC(C)=N2

Molecular Formula

C19H22N6OS

Molecular Weight

382.48

References & Citations

[1]Layton ME, et, al. Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia. J Med Chem. 2023 Jan 26;66 (2) :1157-1171.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PDE10

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