(1R,2R) -Elpipodect
(1R,2R) -Elpipodect ((1R,2R) -MK-8189) is the (1R,2R) enantiomer of Elpipodect (HY-153093) . Elpipodect (MK-8189) is an orally active and selective PDE10A inhibitor with a Ki of 29 pM. Elpipodect can be used in research of schizophrenia[1].
Product Specifications
CAS Number
[1424378-99-3]
Product Name Alternative
(1R,2R) -MK-8189
UNSPSC
12352100
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Smiles
CC(S1)=NN=C1CNC2=CC(OC[C@H]3[C@H](C4=CC=C(C=N4)C)C3)=NC(C)=N2
Molecular Formula
C19H22N6OS
Molecular Weight
382.48
References & Citations
[1]Layton ME, et, al. Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia. J Med Chem. 2023 Jan 26;66 (2) :1157-1171.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE10
Curated Selection
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