Belumosudil (Standard)
Belumosudil (Standard) is the analytical standard of Belumosudil. This product is intended for research and analytical applications. Belumosudil (KD025) is a selective inhibitor of ROCK2 with IC50s of 105 nM and 24 μM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties[1].
Product Specifications
CAS Number
911417-87-3
UNSPSC
12352100
Target
Reference Standards; ROCK
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Others; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Inflammation/Immunology; Cancer
Smiles
O=C(NC(C)C)COC1=CC=CC(C2=NC(NC3=CC4=C(NN=C4)C=C3)=C5C=CC=CC5=N2)=C1
Molecular Formula
C26H24N6O2
Molecular Weight
452.51
References & Citations
[1]Boerma, M., et al. Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase. Blood Coagul Fibrinolysis. 2008 Oct;19 (7) :709-18.|[2]Lee, J.H., et al. Selective ROCK2 Inhibition In Focal Cerebral Ischemia. Ann Clin Transl Neurol. 2014 Jan 1;1 (1) :2-14.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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