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PRMT5-IN-46

PRMT5-IN-46 (compound 278) inhibits PRMT5 with IC50s of 1-10 μM. PRMT5 is a methyltransferase which is associated with specific genetic alterations. PRMT5-IN-46 can be used for research of proliferative diseases, metabolic disorders, and blood diseases[1].

Product Specifications

CAS Number

380192-76-7

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Histone Methyltransferase

Related Pathways

Epigenetics

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Smiles

ClC1=CC=C(COCC(CN2CC3=C(CC2)C=CC=C3)O)C=C1

Molecular Formula

C19H22ClNO2

Molecular Weight

331.84

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]DUNCAN, et al. PRMT5 inhibitors and uses thereof. WO2014100695. World Intellectual Property Organization. 2014-06-26.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 1

Frequently Asked Questions

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