PRMT5-IN-46
PRMT5-IN-46 (compound 278) inhibits PRMT5 with IC50s of 1-10 μM. PRMT5 is a methyltransferase which is associated with specific genetic alterations. PRMT5-IN-46 can be used for research of proliferative diseases, metabolic disorders, and blood diseases[1].
Product Specifications
CAS Number
380192-76-7
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Histone Methyltransferase
Related Pathways
Epigenetics
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Smiles
ClC1=CC=C(COCC(CN2CC3=C(CC2)C=CC=C3)O)C=C1
Molecular Formula
C19H22ClNO2
Molecular Weight
331.84
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]DUNCAN, et al. PRMT5 inhibitors and uses thereof. WO2014100695. World Intellectual Property Organization. 2014-06-26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
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