Mal-amide-PEG8-Val-Cit-PAB-OH
Mal-amide-PEG8-Val-Cit-PAB-OH is a cleavable ADC linker featuring a maleimide, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB functional group. Maleimide is used to covalently bind free thiols on the cysteine residues of proteins. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery with the help of the PAB structure.
Product Specifications
CAS Number
[2387738-43-2]
UNSPSC
12352203
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Field of Research
Cancer
Smiles
CC(C)[C@@H](C(N[C@H](C(NC1=CC=C(C=C1)CO)=O)CCCNC(N)=O)=O)NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN(C(C=C2)=O)C2=O)=O)=O
Molecular Formula
C44H71N7O16
Molecular Weight
954.07
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Curated Selection
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