Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Reparixin (Standard)

Reparixin (Standard) is the analytical standard of Reparixin. This product is intended for research and analytical applications. Reparixin is a non-competitive allosteric inhibitor of the chemokine receptors CXCR1 and CXCR2 activation with IC50s of 1 and 100 nM, respectively.

Product Specifications

CAS Number

266359-83-5

UNSPSC

12352100

Target

CXCR; Reference Standards

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Others

Field of Research

Inflammation/Immunology; Endocrinology; Cancer

Smiles

CS(=O)(NC([C@@H](C1=CC=C(CC(C)C)C=C1)C)=O)=O

Molecular Formula

C14H21NO3S

Molecular Weight

283.39

References & Citations

[1]Moriconi A, et al. Design of noncompetitive interleukin-8 inhibitors acting on CXCR1 and CXCR2. J Med Chem. 2007 Aug 23;50 (17) :3984-4002.|[2]Bertini R, et al. Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2non-competitive allosteric inhibitor. Br J Pharmacol. 2012 Jan;165 (2) :436-54.|[3]Kim HY, et al. Reparixin, an inhibitor of CXCR1 and CXCR2 receptor activation, attenuates blood pressure and hypertension-related mediators expression in spontaneously hypertensive rats. Biol Pharm Bull. 2011;34 (1) :120-7.|[4]Sousa LF, et al. Blockade of CXCR1/2 chemokine receptors protects against brain damage in ischemic stroke in mice. Clinics (Sao Paulo) . 2013;68 (3) :391-4.|[5]Bertini R, et al. Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. Proc Natl Acad Sci U S A. 2004 Aug 10;101 (32) :11791-6.|[6]Krishnamurthy A, et al. Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss. Ann Rheum Dis. 2016 Apr;75 (4) :721-9.|[7]Crespo J, et al. Human Naive T Cells Express Functional CXCL8 and Promote Tumorigenesis. J Immunol. 2018 Jul 15;201 (2) :814-820.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

L-Proline-N-Fmoc
TRC-P756005-1G 1 g

L-Proline-N-Fmoc

Sign In for Pricing
View Details
C2orf68 (NM_001013649) Human Over-expression Lysate
LC423002 20 µg

C2orf68 (NM_001013649) Human Over-expression Lysate

Sign In for Pricing
View Details
Micronomicin Sulfate (~80%)
TRC-M342900-1G 1 g

Micronomicin Sulfate (~80%)

Sign In for Pricing
View Details
Trichostatin A
P010-1MG 1 Each

Trichostatin A

Sign In for Pricing
View Details
ITIH5 Human Gene Knockout Kit (CRISPR)
KN214478RB 1 Kit

ITIH5 Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
Human IGIP activation kit by CRISPRa
GA118575 1 Kit

Human IGIP activation kit by CRISPRa

Sign In for Pricing
View Details