Menin-MLL inhibitor MI-2 (dihydrochloride)
Menin-MLL inhibitor MI-2 dihydrochloride is a competitive and selective Menin-MLL interaction inhibitor with an IC50 value of 446 nM and a Ki value of 158 nM. Menin-MLL inhibitor MI-2 dihydrochloride downregulates the expression of target genes such as HOXA9 and MEIS1, inhibits proliferation of leukemia cells and induces apoptosis and differentiation. Menin-MLL inhibitor MI-2 dihydrochloride is proming for rasearch of MLL-rearranged acute leukemias (e.g., AML, ALL) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Epigenetic Reader Domain
Related Pathways
Apoptosis; Epigenetics
Field of Research
Cancer
Smiles
CCCC1=CC2=C(N=CN=C2S1)N3CCN(CC3)C4=NCC(C)(S4)C.Cl.Cl
Molecular Formula
C18H27Cl2N5S2
Molecular Weight
448.48
References & Citations
[1]Grembecka J, et al. Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nat Chem Biol. 2012 Jan 29;8 (3) :277-84.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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