Tonabersat-d6
Tonabersat-d6 (SB-220453-d6) is deuterium labeled Tonabersat. Tonabersat (SB-220453) is a gap-junction modulator. Tonabersat prevents inflammatory damage in the central nervous system[1][2][3].
Product Specifications
CAS Number
1329837-33-3
Product Name Alternative
SB-220453-d6
UNSPSC
12352005
Target
Gap Junction Protein; Isotope-Labeled Compounds
Related Pathways
Cytoskeleton; Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
O=C(C1=CC(Cl)=C(C=C1)F)N[C@H]2C3=CC(C(C)=O)=CC=C3OC(C([2H])([2H])[2H])([C@H]2O)C([2H])([2H])[2H]
Molecular Formula
C20H13D6ClFNO4
Molecular Weight
397.86
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Chen Q, et al. Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer. Nature. 2016 May 18;533 (7604) :493-8.|[3]Silberstein SD, et al.
 Tonabersat, a gap-junction modulator: efficacy and safety in two randomized, placebo-controlled, dose-ranging studies of acute migraine.
 Cephalalgia. 2009 Nov;29 Suppl 2:17-27.|[4]Kim Y, et al. Tonabersat Prevents Inflammatory Damage in the Central Nervous System by Blocking Connexin43 Hemichannels. Neurotherapeutics. 2017 May 30.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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