Tonabersat-d6

Tonabersat-d6 (SB-220453-d6) is deuterium labeled Tonabersat. Tonabersat (SB-220453) is a gap-junction modulator. Tonabersat prevents inflammatory damage in the central nervous system[1][2][3].

Product Specifications

CAS Number

[1329837-33-3]

Product Name Alternative

SB-220453-d6

UNSPSC

12352005

Target

Gap Junction Protein; Isotope-Labeled Compounds

Related Pathways

Cytoskeleton; Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

O=C(C1=CC(Cl)=C(C=C1)F)N[C@H]2C3=CC(C(C)=O)=CC=C3OC(C([2H])([2H])[2H])([C@H]2O)C([2H])([2H])[2H]

Molecular Formula

C20H13D6ClFNO4

Molecular Weight

397.86

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Chen Q, et al. Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer. Nature. 2016 May 18;533 (7604) :493-8.|[3]Silberstein SD, et al. Tonabersat, a gap-junction modulator: efficacy and safety in two randomized, placebo-controlled, dose-ranging studies of acute migraine. Cephalalgia. 2009 Nov;29 Suppl 2:17-27.|[4]Kim Y, et al. Tonabersat Prevents Inflammatory Damage in the Central Nervous System by Blocking Connexin43 Hemichannels. Neurotherapeutics. 2017 May 30.