Dimethylcurcumin (Standard)
Dimethylcurcumin (Standard) is the analytical standard of Dimethylcurcumin. This product is intended for research and analytical applications. Dimethylcurcumin (ASC-J9) is an androgen receptor degradation enhancer that effectively suppresses castration resistant prostate cancer cell proliferation and invasion.
Product Specifications
CAS Number
52328-98-0
UNSPSC
12352100
Target
Androgen Receptor; Reference Standards
Related Pathways
Others; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
O=C(/C=C(O)/C=C/C1=CC=C(OC)C(OC)=C1)/C=C/C2=CC=C(OC)C(OC)=C2
Molecular Formula
C23H24O6
Molecular Weight
396.43
References & Citations
[1]Yamashita S, et al. 
 ASC-J9 suppresses castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors.
 Neoplasia. 2012 Jan;14 (1) :74-83.|[2]Yang Z, et al. 
 ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor.
 Nat Med. 2007 Mar;13 (3) :348-53.|[3]Lee SO, et al. 
 New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs non-stem/progenitor cells.
 J Mol Cell Biol. 2012 Jul 24.|[4]Ma W, et al. Targeting androgen receptor with ASC-J9 attenuates cardiac injury and dysfunction in experimental autoimmune myocarditis by reducing M1-like macrophage. Biochem Biophys Res Commun. 2017 Apr 15;485 (4) :746-752. doi: 10.1016/j.bbrc.2017.02.123. Epub 2017 Feb 27.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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