Nirogacestat (Standard)

Nirogacestat (Standard) is the analytical standard of Nirogacestat. This product is intended for research and analytical applications. Nirogacestat (PF-3084014) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC50 of 6.2 nM. Inhibition of Notch signaling by Nirogacestat while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers[1].

Product Specifications

CAS Number

[1290543-63-3]

UNSPSC

12352100

Target

Apoptosis; Reference Standards; γ-secretase

Related Pathways

Apoptosis; Neuronal Signaling; Others; Stem Cell/Wnt

Field of Research

Cancer

Smiles

FC1=C2C(CC[C@H](N[C@@H](CCC)C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)=O)C2)=CC(F)=C1

Molecular Formula

C27H41F2N5O

Molecular Weight

489.64

References & Citations

[1]Wei P, et al. Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design. Mol Cancer Ther. 2010 Jun;9 (6) :1618-28.