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Buparlisib (Hydrochloride) (Standard)

Buparlisib (Hydrochloride) (Standard) is the analytical standard of Buparlisib (Hydrochloride) . This product is intended for research and analytical applications. Buparlisib Hydrochloride (BKM120 Hydrochloride) is a pan-class I PI3K inhibitor, with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/p110β/p110δ/p110γ, respectively.

Product Specifications

CAS Number

1312445-63-8

UNSPSC

12352100

Target

Apoptosis; PI3K; Reference Standards

Related Pathways

Apoptosis; Others; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

NC(N=C1)=CC(C(F)(F)F)=C1C2=NC(N3CCOCC3)=NC(N4CCOCC4)=C2.[H]Cl

Molecular Formula

C18H22ClF3N6O2

Molecular Weight

446.85

References & Citations

[1]Burger MT, et al. Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer. ACS Med Chem Lett. 2011 Aug 26;2 (10) :774-9.|[2]Zheng Y, et al. Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows synergistic anti-myeloma activity with dexamethasone. J Mol Med (Berl) . 2012 Jun;90 (6) :695-706.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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