Pyridostatin (trihydrochloride)

Pyridostatin (RR82) trihydrochloride is a G-quadruplex DNA stabilizing agent (Kd=490 nM) and can target DNA and RNA G4s in cells. Pyridostatin trihydrochloride promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin trihydrochloride targets the proto-oncogene Src. Pyridostatin trihydrochloride reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells[1][2].

Product Specifications

CAS Number

[2517456-88-9]

Product Name Alternative

RR82 (trihydrochloride)

UNSPSC

12352100

Target

G-quadruplex

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Purity

98.06

Smiles

O=C(C1=CC(OCCN)=CC(C(NC2=NC3=C(C(OCCN)=C2)C=CC=C3)=O)=N1)NC4=CC(OCCN)=C5C=CC=CC5=N4.Cl.Cl.Cl

Molecular Formula

C31H35Cl3N8O5

Molecular Weight

706.02

References & Citations

[1]Rodriguez R, et al. Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol. 2012;8 (3) :301-310. Published 2012 Feb 5.|[2]Koirala D, et al. A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat Chem. 2011;3 (10) :782-787. Published 2011 Aug 28.