Dactolisib (Tosylate) (Standard)

Dactolisib (Tosylate) (Standard) is the analytical standard of Dactolisib (Tosylate) . This product is intended for research and analytical applications. Dactolisib Tosylate (BEZ235 Tosylate) is a dual PI3K and mTOR kinase inhibitor with IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively. Dactolisib Tosylate (BEZ235 Tosylate) inhibits mTORC1 and mTORC2.

Product Specifications

CAS Number

[1028385-32-1]

UNSPSC

12352100

Hazard Statement

H302, H312, H332

Target

Autophagy; mTOR; PI3K; Reference Standards

Related Pathways

Autophagy; Others; PI3K/Akt/mTOR

Field of Research

Cancer

Purity

98.95

Smiles

CN(C1=C2C3=CC(C4=CC5=CC=CC=C5N=C4)=CC=C3N=C1)C(N2C6=CC=C(C=C6)C(C)(C#N)C)=O.CC7=CC=C(S(=O)(O)=O)C=C7

Molecular Formula

C37H31N5O4S

Molecular Weight

641.74

Precautions

H302, H312, H332

References & Citations

[1]Maira SM, et al. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther, 2008, 7 (7), 1851-1863.