Trisulfo-Cy3 Methyltetrazine

Trisulfo-Cy3 Methyltetrazine is a click chemistry reagent containing an methyltetrazine group. Methyltetrazine-activated Cy3 probe reacts with TCO-containing compounds via an Inverse-Electron-Demand Diels-Alder reaction to form a stable covalent bond and does not require Cu-catalyst or elevated temperatures[1][2].

Product Specifications

CAS Number

[1676067-48-3]

UNSPSC

12352005

Target

ADC Linker

Related Pathways

Antibody-drug Conjugate/ADC Related

Field of Research

Others

Solubility

10 mM in DMSO

Smiles

O=C(CCCCCN1C2=CC=C(S(=O)(O)=O)C=C2C(C)(C)/C1=C\C=C\C3=[N+](CCCS(=O)(O)=O)C4=C(C3(C)C)C=C(S(=O)([O-])=O)C=C4)NCC5=CC=C(C6=NN=C(C)N=N6)C=C5

Molecular Formula

C42H49N7O10S3

Molecular Weight

908.07

References & Citations

[1]Cy3 Methyltetrazine. |[2]Vera F C Ferreira, et al. In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry. Bioconjug Chem. 2021 Jan 20;32 (1) :121-132.