4-Azido-2,3,5,6-tetrafluorobenzoic Acid
4-Azido-2,3,5,6-tetrafluorobenzoic Acid (N3-TFBA) is a click chemistry reagent containing an azide group. 4-Azido-2,3,5,6-tetrafluorobenzoic Acid is a complex with FAM-labeled DNA probe. 4-Azido-2,3,5,6-tetrafluorobenzoic Acid can be used as versatile photoaffinity labeling agents to probe biological receptors. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
Product Specifications
CAS Number
[122590-77-6]
Product Name Alternative
N3-TFBA
UNSPSC
12171500
Hazard Statement
H228, H315, H319
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Others
Purity
98.97
Solubility
10 mM in DMSO
Smiles
[N-]=[N+]=NC1=C(C(F)=C(C(F)=C1F)C(O)=O)F
Molecular Formula
C7HF4N3O2
Molecular Weight
235.10
Precautions
H228, H315, H319
References & Citations
[1]Li G, et al. Multivalent photoaffinity probe for labeling small molecule binding proteins. Bioconjug Chem. 2014 Jun 18;25 (6) :1172-80.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Available Sizes
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