Calcitetrol

Calcitetrol (1α, 24, 25-Trihydroxy VD3) is the hormonally active form of vitamin D with three hydroxyl groups. IC50 value: Target: Calcitriol increases blood calcium levels ([Ca2+]) by promoting absorption of dietary calcium from the gastrointestinal tract and increasing renal tubular reabsorption of calcium, thus reducing the loss of calcium in the urine. Calcitriol also stimulates release of calcium from bone by its action on the specific type of bone cells referred to as osteoblasts, causing them to release RANKL, which in turn activates osteoclasts.

Product Specifications

CAS Number

[72203-93-1]

Product Name Alternative

1α, 24, 25-Trihydroxy VD3

UNSPSC

12352211

Target

VD/VDR

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Purity

99.86

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@@H](C[C@H](O)C/1=C)CC1=C\C=C2[C@@](CC[C@@H]3[C@@H](CCC(O)C(C)(O)C)C)([H])[C@]3(C)CCC\2

Molecular Formula

C27H44O4

Molecular Weight

432.64

References & Citations

[1]Akiyoshi-Shibata M, et al. Further oxidation of hydroxycalcidiol by calcidiol 24-hydroxylase. A study with the mature enzyme expressed in Escherichia coli. Eur J Biochem. 1994 Sep 1;224 (2) :335-43.