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(R, S) -YAP-TEAD-IN-2

(R, S) -YAP-TEAD-IN-2 is the racemic mixture of YAP-TEAD-IN-2. YAP-TEAD-IN-2 (Compound 6) is a potent inhibitor of YAP-TEAD PPIs (protein-protein interaction) with an IC50 of 2.7 nM[1].

Product Specifications

UNSPSC

12352005

Target

YAP

Related Pathways

Stem Cell/Wnt

Field of Research

Cancer

Purity

98.26

Smiles

NC[C@@]1(C2=CC=CC=C2)CC3=[C@](C(Cl)=CC=C3O1)[C@]4=C(C(N)=O)C=Cc(OCCOC)c4F

Molecular Formula

C25H24ClFN2O4

Molecular Weight

470.92

References & Citations

[1]Furet P, et al. The First Class of Small Molecules Potently Disrupting the YAP-TEAD Interaction by Direct Competition. ChemMedChem. 2022 Oct 6;17 (19) :e202200303.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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