(R, S) -YAP-TEAD-IN-2
(R, S) -YAP-TEAD-IN-2 is the racemic mixture of YAP-TEAD-IN-2 (HY-151525) . YAP-TEAD-IN-2 (Compound 6) is a potent inhibitor of YAP-TEAD PPIs (protein-protein interaction) with an IC50 of 2.7 nM[1].
Product Specifications
UNSPSC
12352005
Target
YAP
Related Pathways
Stem Cell/Wnt
Field of Research
Cancer
Purity
98.26
Smiles
NC[C@@]1(C2=CC=CC=C2)CC3=[C@](C(Cl)=CC=C3O1)[C@]4=C(C(N)=O)C=Cc(OCCOC)c4F
Molecular Formula
C25H24ClFN2O4
Molecular Weight
470.92
References & Citations
[1]Furet P, et al. The First Class of Small Molecules Potently Disrupting the YAP-TEAD Interaction by Direct Competition. ChemMedChem. 2022 Oct 6;17 (19) :e202200303.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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