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SRT 1720 (monohydrochloride) (Standard)

SRT 1720 (monohydrochloride) (Standard) is the analytical standard of SRT 1720 (monohydrochloride) . This product is intended for research and analytical applications. SRT 1720 monohydrochloride is a selective and orally active activator of SIRT1 with an EC50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3[1].

Product Specifications

CAS Number

2060259-60-9

UNSPSC

12352100

Target

Autophagy; Reference Standards; Sirtuin

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Epigenetics; Others

Field of Research

Metabolic Disease

Smiles

O=C(C1=NC2=CC=CC=C2N=C1)NC3=C(C=CC=C3)C4=CN5C(CN6CCNCC6)=CSC5=N4.Cl

Molecular Formula

C25H24ClN7OS

Molecular Weight

506.02

References & Citations

[1]Milne JC et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29;450 (7170) :712-6|[2]Baur JA, et al. Are sirtuins viable targets for improving healthspan and lifespan?, Nat Rev Drug Discov. 2012 Jun 1;11 (6) :443-61|[3]Yao H, et al. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice., J Clin Invest. 2012 Jun 1;122 (6) :2032-45.|[4]Gao D, et al. Activation of SIRT1 Attenuates Klotho Deficiency-Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity. Hypertension. 2016 Nov;68 (5) :1191-1199.|[5]Lahusen TJ, et al. SRT1720 induces lysosomal-dependent cell death of breast cancer cells. Mol Cancer Ther. 2015 Jan;14 (1) :183-92.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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